EC Number |
Natural Substrates |
---|
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
regulation of enzyme |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
first enzyme of cardiolipin biosynthetic pathway |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
essential for normal cardiolipin content of cells |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
involved in synthesis of phosphatidylglycerol |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
the enzyme catalyzes the first committed step in synthesis of cardiolipid. In response to inositol, decrease in Pgs1p enzyme activity is associated with increased phosphorylation of Pgs1p. Phosphorylation of a phospholipid biosynthetic enzyme in response to inositol, new mechanism of inositol-mediated regulation |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate |
cardiolipin (phospholipid) biosynthesis, regulation by short chain cell-permeable ceramide (C2-Cer: N-acetylsphingosine) signalling and levels of active GTP-bound RhoA |
2.7.8.5 | CDP-diacylglycerol + sn-glycerol 3-phosphate |
- |
2.7.8.5 | more |
enzyme of synthetic pathway of phosphatidylglycerol |
2.7.8.5 | more |
essential enzyme in biosynthesis of cardiolipin. The KlPGS1 gene is essential for Kluyveromyces lactis |