EC Number   |
Natural Substrates |
|---|
   2.7.7.52 | more |
- |
| 2.7.7.52 | more |
reduction of isozyme RET1 leads to decrease in edited RNA and inhibited growth, lowers the uridine insertion and leads predominantly to shorter gRNAs |
| 2.7.7.52 | more |
down-regulation of isozyme RET2 inhibits growth and in vivo uridine insertion, but has no effect on the length of gRNAs |
| 2.7.7.52 | more |
enzyme interacts with a minor fraction of total RNA ligase |
| 2.7.7.52 | more |
many editing changes are developmentally regulated |
| 2.7.7.52 | more |
down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails |
| 2.7.7.52 | more |
Inhibition of RNA editing by down-regulation of expression of the mitochondrial RNA editing TUTase 1 by RNA interference has profound effects on kinetoplast biogenesis in Trypanosoma brucei procyclic cells. De novo synthesis of the apocytochrome b and cytochrome oxidase subunit I proteins is no longer detectable after 3 days of RNAi. The effect on protein synthesis correlates with a decline in the levels of the assembled mitochondrial respiratory complexes III and IV, and also with cyanide-sensitive oxygen uptake. The steady-state levels of nuclear-encoded subunits of complexes III and IV are also significantly decreased. Because the levels of the corresponding mRNAs are not affected, the observed effect is likely due to an increased turnover of these imported mitochondrial proteins. This induced protein degradation is selective for components of complexes III and IV, because little effect is observed on components of the F1-F0 -ATPase complex and on several other mitochondrial proteins |
| 2.7.7.52 | more |
post-transcriptional uridylylation of guide RNAs by RNA editing TUTase 1 or RET1, a multi-functional RNA processing enzyme, and U-insertion mRNA editing by RNA editing TUTase 2 or RET2, biological functions of TUT isozymes, RNA processing in mitochondria of trypanosomes, detailed overview |
| 2.7.7.52 | UTP + miR-1003 RNAn |
- |
| 2.7.7.52 | UTP + miR-324n |
- |
