EC Number |
Natural Substrates |
---|
2.7.7.49 | 2'-deoxyribonucleoside triphosphate + DNAn |
enzyme mutant N483Q/S486Q/T539N/Y545Q/D547T/P548Q/A570Q/D578Q/A597T/W604R/S612N/V730L/R736Q/S739N/M747R |
2.7.7.49 | a 2'-deoxyribonucleoside 5'-triphosphate + DNAn |
- |
2.7.7.49 | dATP + DNAn |
- |
2.7.7.49 | dATP + DNAn |
RNA-dependent DNA synthesis |
2.7.7.49 | dCTP + DNAn |
- |
2.7.7.49 | deoxynucleoside triphosphate + DNAn |
- |
2.7.7.49 | deoxynucleoside triphosphate + DNAn |
the alpha enzyme form is more active in the single-strand cDNA-directed synthesis of double-stranded cDNA-directed synthesis of double-stranded DNA than the other 2 enzyme forms |
2.7.7.49 | deoxynucleoside triphosphate + DNAn |
the enzyme appears to be required very early after infection to synthesize proviral DNA |
2.7.7.49 | deoxynucleoside triphosphate + DNAn |
the enzyme might play a role in normal differentiation |
2.7.7.49 | deoxynucleoside triphosphate + DNAn |
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections |