EC Number |
Natural Substrates |
---|
2.7.7.41 | CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid |
- |
2.7.7.41 | CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid |
- |
2.7.7.41 | CTP + phosphatidate |
- |
2.7.7.41 | CTP + phosphatidate |
the enzyme is involved in the regulation of phospholipid metabolism |
2.7.7.41 | CTP + phosphatidate |
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme |
2.7.7.41 | CTP + phosphatidate |
enzyme plays a central role in phospholipid biosynthesis |
2.7.7.41 | CTP + phosphatidate |
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids |
2.7.7.41 | CTP + phosphatidate |
the enzyme is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-diphosphate from phosphatidic acid. A photoreceptor cell-specific isoform is a key regulator of phototransduction, a G-protein-coupled signalling cascade mediated by phospholipase C |
2.7.7.41 | CTP + phosphatidate |
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate |
2.7.7.41 | CTP + phosphatidate |
regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity |