EC Number   |
Natural Substrates |
|---|
   2.7.11.8 | ATP + TIA-1 |
rapidly activated during Fas-mediated apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in signaling downstream events in the apoptotic program |
| 2.7.11.8 | ATP + TIA-1 |
FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis |
| 2.7.11.8 | ATP + [Fas-activated serine/threonine protein] |
- |
| 2.7.11.8 | ATP + [T-cell intracellular antigen 1] |
FAST K is known to interact with and phosphorylate TIA-1, effects of FAST K on other splicing factors and associated splicing regulatory motifs are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1 and TIA-related proteins, interaction analysis of FAST K with TIA, overview |
| 2.7.11.8 | more |
FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST is a survival protein, modulating the NF-kappaB-dependent survival pathway, and has antiapoptotic effects inhibiting Fas-and UV-induced apoptosis, involving activation of caspase-3, its antiapoptotic effects are inhibited by TIA-1, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis |
| 2.7.11.8 | more |
the interaction of the enzyme with protein BCL-XL is involved in regulation of mitochondrial metabolism during Fas-induced apoptosis |
| 2.7.11.8 | more |
Fas signaling is connected with the activity of splicing factors that modulate Fas alternative splicing, suggesting the existence of an autoregulatory loop that could serve to amplify Fas responses, overview |
