EC Number   |
Natural Substrates |
|---|
   2.7.11.4 | ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase |
inactivation of the substrate enzyme |
| 2.7.11.4 | ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase |
the catalyzed reversible specific phosphorylation of the BCKD subunit regulates the first committed step in the pathway for leucine, isoleucine, and valine catabolism |
| 2.7.11.4 | ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase |
the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism |
| 2.7.11.4 | ATP + mitogen-activated protein kinase kinase |
the enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct MEK phosphorylation |
| 2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] |
- |
| 2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] |
inactivation by phosphorylation of BCKDH |
| 2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] |
phosphorylation-mediated inactivation of the E1alpha subunit of branched-chain ketoacid dehydrogenase, BCKDH |
| 2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] |
the enzyme (BCKDK) phosphorylates Ser293 of the E1alpha subunit of the BCKDH protein, which catalyzes the rate-limiting step in the catabolism of the branched-chain amino acids (BCAAs), inhibiting 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) (BCKDH) and thereby, limiting breakdown of the BCAAs |
| 2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] |
branched-chain amino acid metabolism |
| 2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] |
regulatory enzyme of branched-chain 2-oxoacid dehydrogenase complex |
