EC Number |
Natural Substrates |
---|
2.7.11.30 | ATP + Smad |
involved in ALK5 activation of p38 MAPK signaling and of GADDbeta45 and BGN expression induced by TGF-beta |
2.7.11.30 | ATP + Smad1 |
phosphorylation by ALK1 |
2.7.11.30 | ATP + Smad2 |
- |
2.7.11.30 | ATP + Smad2 |
ALK7 is involved in regulation of cell proliferation and apoptosis, regulation, overview |
2.7.11.30 | ATP + Smad2 |
GDF-9-induced phosphorylation |
2.7.11.30 | ATP + Smad2 |
phosphorylation by ALK5 |
2.7.11.30 | ATP + Smad2 |
step in the MAPK signaling pathway via JNK and p38 |
2.7.11.30 | ATP + Smad2 |
TGF-beta- or actividin-induced phosphorylation |
2.7.11.30 | ATP + Smad2 |
TGF-beta-induced phosphorylation by TbetaRI receptor kinase at both phosphorylation sites Ser465 and Ser467 leads to release of Smad2 from membrane-anchored protein SARA and signaling co-mediator Smad4, translocation into the nucleus, and regulation of target gene expression |
2.7.11.30 | ATP + Smad2 |
TGF-beta-mediated activation of Smad2 by the TGF-beta receptor |