EC Number |
Natural Substrates |
---|
2.7.11.15 | ATP + a protein |
- |
2.7.11.15 | ATP + alpha-synuclein |
colocalization of GRK2, GRK5, alpha-synuclein, and tau in neurodegenerative disorders characterized by fibrillary tau inclusions and/or alpha-synuclein-enriched Lewy bodies, overview |
2.7.11.15 | ATP + alpha1 beta-adrenergic receptor |
substrate specificities of GRK2 and GRK3 in cardiac myocytes, overview |
2.7.11.15 | ATP + alpha1-adrenergic receptor |
- |
2.7.11.15 | ATP + alpha1D-adrenergic receptor |
inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction and signalling, overview |
2.7.11.15 | ATP + alpha2A-adrenergic receptor |
- |
2.7.11.15 | ATP + angiotensin receptor |
phosphorylation by GRK2 preceeds the binding of arrestins, which inhibits the seven-transmembrane receptor, but initiates internalization, overview |
2.7.11.15 | ATP + beta-adrenergic receptor |
- |
2.7.11.15 | ATP + beta-adrenergic receptor |
general role in the desensitization of synaptic receptors |
2.7.11.15 | ATP + beta-adrenergic receptor |
specifically phosphorylates and inactivates beta-AR after stimulation by receptor agonists, facilitating the binding of the inhibitor protein beta-arrestin to the receptor, during myocardial ischemia the membrane activity of beta-ARK is increased |