EC Number |
Natural Substrates |
---|
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
- |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
enzyme activity is regulated by cAMP levels. This regulation may be critical in the initiation of cell growth for which 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate seems to be necessary |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
the activity of the enzyme is regulated by the reversible balance between cAMP-dependent protein kinase-dependent phosphorylation and protein phosphatase 1-dependent dephosphorylation |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
the enzyme catalyzes the last step in the synthesis of phosphatidylinositol 4,5-bisphosphate, which is a precursor of diacylglycerol and inositol 1,4,5-triphosphate and is also involved in regulation of actin cytoskeleton remodeling and membrane traffic. The enzyme is regulated by casein kinase Cki1 |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
enzyme type 1beta is essential for epidermal growth factor receptor-mediated endocytosis |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
the MSS4 gene product functions in regulation of actin-binding proteins through generation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from 1-phosphatidyl-1D-myo-inositol 4-phosphate in or near the plasma membrane |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
in addition to regulating early steps in endocytosis, the enzyme acts through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to regulate endosomal trafficking and/or fusion |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
the product 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate |
2.7.1.68 | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
Rho-kinase is involved in the Rho-controlled synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate by phosphatidylinositol-4-phosphate 5-kinase |