EC Number |
Natural Substrates |
---|
2.7.1.146 | ADP + D-fructose 1,6-bisphosphate |
- |
2.7.1.146 | ADP + D-fructose 6-phosphate |
- |
2.7.1.146 | ADP + D-fructose 6-phosphate |
the enzyme is involved in the modified Embden-Meyerhof pathway |
2.7.1.146 | ADP + D-fructose 6-phosphate |
key enzyme of the glycolytic pathway |
2.7.1.146 | ADP + D-glucose |
the enzyme phosphorylates both D-glucose and D-fructose 6-phosphate. Binding of both substrates to the same active site. At a sugar concentration of 10 mM the acctivity with D-fructose 6-phosphate is about 75% compared to the activity with D-glucose. No activity in presence of ATP. kcat/KM for the phosphorylation of D-fructose 6-phosphate is 440fold higher than the kcat/Km for the phosphorylation of glucose. Analysis of the kcat/Km ratios shows that the glucose dephosphorylation is 2fold more effective than the phosphorylation |
2.7.1.146 | ATP + D-fructose 6-phosphate |
- |
2.7.1.146 | D-fructose 6-phosphate + ADP |
- |
2.7.1.146 | D-fructose 6-phosphate + ADP |
ADP can be replaced by GDP and CDP to a limited extent |
2.7.1.146 | D-fructose 6-phosphate + ADP |
ADP can be replaced by acetylphosphate |
2.7.1.146 | D-fructose 6-phosphate + ADP |
ADP can be replaced by GDP, ATP and GTP to a limited extent |