EC Number   |
Natural Substrates |
|---|
   2.7.1.137 | ATP + 1-phosphatidyl-1D-myo-inositol |
- |
| 2.7.1.137 | ATP + 1-phosphatidyl-1D-myo-inositol |
catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex |
| 2.7.1.137 | ATP + 1-phosphatidyl-1D-myo-inositol |
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate |
| 2.7.1.137 | ATP + 1-phosphatidylinositol |
hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network |
| 2.7.1.137 | ATP + Akt1 |
phosphorylation at Ser473, a step in PI3K/Akt signaling |
| 2.7.1.137 | ATP + phosphatidylinositol 4,5-bisphosphate |
- |
| 2.7.1.137 | ATP + phosphatidylinositol 4,5-bisphosphate |
class I enzyme, preferred substrate in vivo |
| 2.7.1.137 | ATP + phosphatidylinositol 4,5-bisphosphate |
class I enzyme, preferred substrate in vivo, physiologic regulation and mode of action |
| 2.7.1.137 | ATP + phosphatidylinositol-4,5-bisphosphate |
- |
| 2.7.1.137 | ATP + phosphatidylinositol-4,5-bisphosphate |
class Ia isozyme |
