EC Number   |
Natural Substrates |
|---|
    2.7.1.108 | CTP + dolichol |
- |
| 2.7.1.108 | CTP + dolichol |
enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules |
| 2.7.1.108 | CTP + dolichol |
CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo |
| 2.7.1.108 | CTP + dolichol |
newly formed dolichyl monophosphate, phosphorylated via CTP is available for biosynthesis of mannosylphosphoryldolichol and N-acetylglucosaminylpyrophosphoryldolichol |
| 2.7.1.108 | CTP + dolichol |
DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate |
| 2.7.1.108 | CTP + dolichol |
DK1 is responsible for the final step of the de novo biosynthesis of dolichol phosphate, defect in human DK1 affects the biosynthesis of dolichol phosphate by the disturbance of the final phosphorylation step, causes lethal phenotype with death in early infancy. |
| 2.7.1.108 | more |
the chain length of eukaryotic dolichol molecules is species specific and differs from 14-17 isoprene units in unicellular organisms like the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, mammalian cells produce longer dolichol molecules with 18-21 isoprene units |
