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EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol -
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol the enzyme functions to recycle diacylglycerol which is generated largely as a by-product of membrane-derived oligosaccharide biosynthesis
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol the enzyme may regulate the intracellular concentration of diacylglycerol
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol the enzyme is involved in resynthesis of phosphatidylinositol by converting a second messenger diacylglycerol to phosphatidic acid
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol DGKiota may have important cellular functions in retina and brain
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol DAGKalpha is stimulated vby Src-like kinase-dependent phosphoinositide 3 kinase activation in lymphocytes. In vivo the increase in cellular levels of Src-like kinase-dependent phosphoinositide 3 kinase products is sufficient to induce DAGKalpha activation, allowing DAGKalpha relocation to the intact lymphocyte
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol nuclear DGK-theta is activated in response to alpha-thrombin
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol the enzyme plays a role in cellular processes by regulating the intracellular concentration of the second messenger diacylglycerol. DGKeta may play a more general role in regulating cellular diacylglycerol levels
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.107ATP + 1,2-diacyl-sn-glycerol high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway
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