EC Number |
Natural Substrates |
---|
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
- |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
the enzyme functions to recycle diacylglycerol which is generated largely as a by-product of membrane-derived oligosaccharide biosynthesis |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
the enzyme may regulate the intracellular concentration of diacylglycerol |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
the enzyme is involved in resynthesis of phosphatidylinositol by converting a second messenger diacylglycerol to phosphatidic acid |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
DGKiota may have important cellular functions in retina and brain |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
DAGKalpha is stimulated vby Src-like kinase-dependent phosphoinositide 3 kinase activation in lymphocytes. In vivo the increase in cellular levels of Src-like kinase-dependent phosphoinositide 3 kinase products is sufficient to induce DAGKalpha activation, allowing DAGKalpha relocation to the intact lymphocyte |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
nuclear DGK-theta is activated in response to alpha-thrombin |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
the enzyme plays a role in cellular processes by regulating the intracellular concentration of the second messenger diacylglycerol. DGKeta may play a more general role in regulating cellular diacylglycerol levels |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1 |
2.7.1.107 | ATP + 1,2-diacyl-sn-glycerol |
high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway |