EC Number |
Natural Substrates |
---|
2.5.1.59 | farnesyl diphosphate + protein-cysteine |
the enzyme catalyzes postttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions |
2.5.1.59 | geranylgeranyl diphosphate + Cdc42-cysteine |
- |
2.5.1.59 | geranylgeranyl diphosphate + Cdc420-cysteine |
- |
2.5.1.59 | geranylgeranyl diphosphate + K Ras-cysteine |
- |
2.5.1.59 | geranylgeranyl diphosphate + N-Ras-cysteine |
- |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine |
- |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine |
enzyme catalyses the transfer of the 20-carbon prenyl group from geranylgeranyl diphosphate to the cysteine residue near the C-termini of a variety of eukaryotic proteins |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine |
this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine |
yeast enzyme is essential for yeast cell growth |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine |
GGTase-I catalyzes C-terminal lipidation of more than 100 proteins, including many GTP-binding regulatory proteins |