EC Number   |
Natural Substrates |
|---|
    2.5.1.22 | more |
levels of spermidine and spermine are not only regulated by activity of spermidine synthase and spermine synthase, but also by other factors, e.g. the level of aminopropyl donor substrate, overview |
| 2.5.1.22 | more |
The predominant polyamines in mammalian cells are spermidine and spermine, these polyamines are made by the sequential addition of aminopropyl groups from decarboxylated S-adenosylmethionine. |
| 2.5.1.22 | more |
spermine synthase is clearly essential for mammalia |
| 2.5.1.22 | more |
spermine synthase is clearly essential for normal development in humans |
| 2.5.1.22 | S-adenosyl 3-(methylthio)propylamine + spermidine |
- |
| 2.5.1.22 | S-adenosylmethioninamine + spermidine |
involved in polyamine biosynthetic pathway |
| 2.5.1.22 | S-adenosylmethioninamine + spermidine |
the enzyme, which is involved in the polyamine biosynthetic pathway in producing the final product spermine, is not essential for plant survival under normal growth conditions |
| 2.5.1.22 | S-adenosylmethioninamine + spermidine |
Polyamine sythesis, addition of a second aminopropyl group to the N-10 position of spermidine. The active site with a bound spermidine molecule contains an Asp276 residue, which is in an ideal position to facilitate the deprotonation of the N-10 amino group of spermidine that attacks the C-atom of the aminopropyl group of decarboxylated S-adenosylmethionine |
| 2.5.1.22 | S-adenosylmethioninamine + spermidine |
decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines |
