EC Number |
Natural Substrates |
---|
2.4.2.4 | 5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate |
the enzyme converts 5-fluorouracil to 5-fluoro-2'-deoxyuridine, activating the prodrug, overview. This action can only take place if there is enough co-substrate. 5-Fluorouracil prodrugs and metabolism, detailed overview |
2.4.2.4 | more |
role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier |
2.4.2.4 | more |
formation of blood/brain barrier and repair following brain injury |
2.4.2.4 | more |
identical to platelet-derived endothelial cell growth factor |
2.4.2.4 | more |
mitogenic effect, promotes endothelial cell proliferation |
2.4.2.4 | more |
angiogenic activity |
2.4.2.4 | more |
expression of PD-ECGF/TP may play an important role in the progression of solid tumors |
2.4.2.4 | more |
important role in nucleoside metabolism, implicated in angiogenesis and apoptosis |
2.4.2.4 | more |
thymidine phosphorylase and uridine phosphorylase contribute in the conversion of 5'-deoxy-5-fluorouridine into 5-fluorouracil and the conversion of 5-fluorouracil into its active metabolites in peripheral blood mononuclear cell, but thymidine phosphorylase seems to be the most important enzyme for these reactions in PBMC |
2.4.2.4 | more |
the enzyme stimulates formation of focal adhesions and the phosphorylation of Tyr397 of focal adhesion kinase, and it induces the expression and/or secretion of other angiogenic factors, overview. Thymidine phosphorylase promotes tumor growth and metastasis by preventing apoptosis and inducing angiogenesis, detailed overview. As gliostatin from fibroma cells, the enzyme inhibits the growth of both astrocytes and glial tumor cells |