EC Number   |
Natural Substrates |
|---|
   2.4.1.87 | more |
- |
| 2.4.1.87 | more |
the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation |
| 2.4.1.87 | more |
synthesis of Ehrlich ascites tumor cell glycoproteins |
| 2.4.1.87 | more |
functions in the biosynthesis of cell surface polylactosaminoglycans on Novikoff cells, attachs a galactose to the N-acetylglucosaminyl residue introduced by EC 2.4.1.149 |
| 2.4.1.87 | more |
functions in the biosynthesis of calf thymocyte cell-surface glycoconjugates including glycoproteins |
| 2.4.1.87 | more |
functions in biosynthesis of calf thymocyte cell-surface glycoconjugates including glycoproteins |
| 2.4.1.87 | more |
involved in the biosynthesis of alpha-D-galactosyl-terminated poly-N-acetyllactosamine glycans that occur on the surface of Ehrlich ascites tumor cells |
| 2.4.1.87 | more |
iGb3S is an additional enzyme capable of synthesizing the xenoreactive Galalpha(1,3)Gal epitope. Galalpha(1,3)Gal synthesized by iGb3S, in contrast to alpha1,3GT, is resistant to downregulation by competition with alpha1,2fucosyltransferase. Galalpha(1,3)Gal synthesized by iGb3S is immunogenic and elicits antibodies in GGTA1-/- mice. Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans |
| 2.4.1.87 | UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R |
- |
| 2.4.1.87 | UDP-alpha-D-galactose + N-acetyllactosamine |
- |
