EC Number |
Natural Substrates |
---|
2.4.1.47 | more |
- |
2.4.1.47 | more |
final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development |
2.4.1.47 | more |
key enzyme in the biosynthesis of cerebrosides and sulfatides, cell-specific and highly time-regulated expression of the CGT gene is thought to play an important role in oligodendrocyte and Schwann cell differentiation |
2.4.1.47 | more |
oligodendrocyte-specific enzyme is involved in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides, time-regulated CGT expression with a peak around postnatal days 15-25 |
2.4.1.47 | more |
last step in biosynthesis of cerebrosides |
2.4.1.47 | more |
enzyme ensures a supply of UDP-galactose in the endoplasmic reticulum lumen by retaining UDP-galactose transporter in a molecular complex |
2.4.1.47 | UDP-galactose + ceramide |
- |
2.4.1.47 | UDPgalactose + 2-(2-hydroxyacyl)sphingosine |
i.e. 2-hydroxy fatty acid ceramide, synthesis of cerebroside |
2.4.1.47 | UDPgalactose + 2-(2-hydroxyacyl)sphingosine |
enzyme may play an important role in the synthesis of at least one type of myelin |
2.4.1.47 | UDPgalactose + 2-(2-hydroxyacyl)sphingosine |
key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS |