EC Number   |
Natural Substrates |
|---|
   2.4.1.206 | more |
essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids |
| 2.4.1.206 | more |
the enzyme is expressed in two distinct phases during the zebrafish embryogenesis. The early phase extends from late blastulation to the completion of epiboly, during which the expression occurs in the superficial layer of the embryos. The second phase of expression starts during mid-segmentation and persists until day 3, during which the expression occurs prominently in the developing lens. Hedgehog signaling is required for the Lc3 synthase expression in embryonic lens |
| 2.4.1.206 | more |
the enzyme synthesizes the key intermediate lactosyltriosylceramide for lacto- and neolactoglycolipids. The large increase in the activity of Lc3 synthase appears to regulate the levels of other neolacto glycolipids, such as Lc3cer, nLc4Cer, nLc6Cer, disialosyl-nLc4Cer and Le(x)-glycolipids |
| 2.4.1.206 | more |
beta3Gn-T2 associates with beta3Gn-T8 in vivo |
| 2.4.1.206 | more |
Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides |
| 2.4.1.206 | UDP-N-acetyl-D-glucosamine + lactosylceramide |
ganglioside metabolism and pattern |
| 2.4.1.206 | UDP-N-acetyl-D-glucosamine + lactosylceramide |
enzyme is active at the branching point of lactosylceramide metabolism, directs lactosylceramide into the glycolipids of the lacto-series |
| 2.4.1.206 | UDP-N-acetyl-D-glucosamine + lactosylceramide |
glycolipid biosynthesis |
| 2.4.1.206 | UDP-N-acetyl-D-glucosamine + lactosylceramide |
biosynthetic pathway of lactoseries and ganglioseries |
| 2.4.1.206 | UDP-N-acetyl-D-glucosamine + lactosylceramide |
may play a key role in regulating the level of various types of lactoseries tumor-associated antigens with the lacto type 1 or 2 chain |
