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Results 1 - 6 of 6

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.4.1.147	more	expression of the enzyme is closely regulated during differentiation and dedifferentiation. Rge expression of the enzyme dramatically decreased in cancerous tissues, and the changes to the core structures of O-glycans give rise to phenotypic changes of cancer cells, such as mobility and metastatic activity
2.4.1.147	more	C3GnT-deficient mice display a discrete, colonspecific reduction in Muc2 protein and increased permeability of the intestinal barrier. These mice are highly susceptible to experimental triggers of colitis and colorectal adenocarcinoma
2.4.1.147	UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-galactosaminyl-Ser/Thr	-
2.4.1.147	UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]	-
2.4.1.147	UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R	R: polypeptide derived from mucin, involved in mucin oligosaccharide biosynthesis
2.4.1.147	UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R	important role in synthesis of mucin-type O-glycans in digestive organs

Results 1 - 6 of 6

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Release 2023.1 (January 2023)