EC Number   |
Natural Substrates |
|---|
   2.4.1.102 | more |
- |
| 2.4.1.102 | more |
patients with Wiskott-Aldrich-Syndrome show an altered enzyme activity and inversed enzyme stimulation in T cells, enzyme activity in platelets is 3fold higher compared to normal organisms |
| 2.4.1.102 | more |
overview: structure of O-glycans |
| 2.4.1.102 | more |
enzyme is developmentally regulated, increased activity in hearts of diabetic organisms, regulation by hyperglycemia and insulin |
| 2.4.1.102 | more |
enzyme activity is increased in patients with chronic myelogenous leukemia CML or acute myeloid leukemia AML |
| 2.4.1.102 | more |
M isoform is upregulated by both all-trans retinoic acid and by IL-4/13. L-isoform is moderately upregulated by IL-4/13 but not by all-trans retinoic acid |
| 2.4.1.102 | more |
multiple C2GlcNAcT enzymes can contribute to P-selectin ligand formation and may cooperate with C2GlcNAcT-I in the control of CD8 T cell trafficking |
| 2.4.1.102 | more |
the enzyme catalyzes the formation of all mucin beta1,6-N-acetylglucosaminides, including core 2, core 4, and blood group I structures |
| 2.4.1.102 | more |
C2GnT-1 regulates selectin ligand expression. Downregulation of the selectin ligand expression level inhibits tissue infiltration of BCP-leukemia cells |
| 2.4.1.102 | more |
glucose levels, plasma TNF-alpha nd core 2 GlcNAc-T activity are functionally linked with dabetic retinopathy |
