EC Number   |
Natural Substrates |
|---|
   2.3.1.67 | 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA |
lyso-PAF, lyso-platelet-activating factor |
| 2.3.1.67 | acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine |
- |
| 2.3.1.67 | acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine |
final step in remodelling pathway of PAF biosynthesis |
| 2.3.1.67 | acetyl-CoA + lyso-platelet activating factor |
- |
| 2.3.1.67 | acetyl-CoA + lyso-platelet-activating factor |
- |
| 2.3.1.67 | more |
the enzyme is activated 1. by a second-order time course after stimulation with platelet-activating factor receptor, 2. by a minute-order time course after LPS stimulation in the MyD88-dependent and p38 MAPK-dependent pathway, and 3. by an hour-order time course after LPS-stimulation in the MyD88-independent and TRIF-independent pathway |
| 2.3.1.67 | more |
enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF |
| 2.3.1.67 | more |
LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine |
