EC Number |
Natural Substrates |
---|
2.3.1.47 | (S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine |
37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, 1 mM S-adenosyl-L-methionine, 2 microM (S)-8-amino-7-oxononanoic acid |
2.3.1.47 | (S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine |
37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, varying S-adenosyl-L-methionine, 9 microM (S)-8-amino-7-oxononanoic acid, varying inhibitor concentration |
2.3.1.47 | 6-carboxyhexanoyl-CoA + L-alanine |
- |
2.3.1.47 | 6-carboxyhexanoyl-CoA + L-alanine |
i.e. pimeloyl-CoA |
2.3.1.47 | 6-carboxyhexanoyl-CoA + L-alanine |
second step in biotin biosynthesis |
2.3.1.47 | 6-carboxyhexanoyl-CoA + L-alanine |
reaction in biotin biosynthesis |
2.3.1.47 | 6-carboxyhexanoyl-CoA + L-alanine |
first committed step in the biotin biosynthesis pathway |
2.3.1.47 | 6-carboxyhexanoyl-CoA + L-alanine |
the enzyme catalyzes the first committed step in the four step pathway, the decarboxylative condensation of L-alanine and pimeloyl-CoA to give (7S)-8-amino-7-oxononanoate |
2.3.1.47 | more |
the enzyme catalyzes the first committed enzyme of the biotin synthesis pathway |
2.3.1.47 | pimeloyl-CoA + L-alanine |
- |