EC Number   |
Natural Substrates |
|---|
   2.3.1.45 | acetyl-CoA + 5-N-acetylneuraminic acid |
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes |
| 2.3.1.45 | acetyl-CoA + 5-N-acetylneuraminic acid |
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. in regulation of cancer development via GD3-O-acetylation, overview |
| 2.3.1.45 | acetyl-CoA + CMP-5-N-acetylneuraminate |
- |
| 2.3.1.45 | acetyl-CoA + CMP-5-N-acetylneuraminic acid |
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes |
| 2.3.1.45 | acetyl-CoA + CMP-5-N-acetylneuraminic acid |
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. terminal alpha2,8-linked sialic acid occurs on the glycerol side chain of GD3, where it reverses FAS-mediated apoptotic effects, suggesting a role of GD3 O-acetylation in regulating induced apoptosis, GD2 O-acetylation is oberseved in breast cancer |
| 2.3.1.45 | acetyl-CoA + CMP-5-N-acetylneuraminic acid |
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. via 9-O-acetylation on colonic mucins, overview |
| 2.3.1.45 | acetyl-CoA + CMP-N-acetylneuraminate |
- |
| 2.3.1.45 | acetyl-CoA + CMP-N-acetylneuraminic acid |
the CMP-N-acetyl-neuraminic acid and acetyl-CoA transporters are critical components for the O-acetylation of CMPNeu5Ac in Golgi lumen, with specific inhibition of either transporter leading to a reduction in the formation of CMP-5-N-acetyl-9-O-acetyl-neuraminic acid, O-acetylation in human colon Golgi vesicles is regulated by the concentration of CMP-Neu5Ac and AcCoA in the lumen, both being under the control of specific transport proteins, overview |
| 2.3.1.45 | acetyl-CoA + ganglioside GD3 |
- |
| 2.3.1.45 | acetyl-CoA + N-acetyl-9-O-acetylneuraminate |
- |
