EC Number |
Natural Substrates |
---|
2.3.1.257 | acetyl-CoA + an N-terminal-L-seryl-[histone H2A] |
- |
2.3.1.257 | acetyl-CoA + an N-terminal-L-seryl-[histone H4] |
- |
2.3.1.257 | acetyl-CoA + an N-terminal-L-seryl-[histone H4] |
efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4 |
2.3.1.257 | acetyl-CoA + N-terminal-L-seryl1-[histone H2A] |
- |
2.3.1.257 | acetyl-CoA + N-terminal-L-seryl1-[histone H4] |
- |
2.3.1.257 | acetyl-CoA + peptide |
hNaa40p preferentially acetylates Ser-Gly-Gly-Gly-Lys- starting peptides |
2.3.1.257 | acetyl-CoA + Ser-Gly-Arg-Gly |
- |
2.3.1.257 | acetyl-CoA + Ser-Gly-Gly-Lys |
- |
2.3.1.257 | more |
hNaa40p is a NAT selectively acetylating Ser-Gly or Gly-Gly starting peptides. NatD also is defined as the catalytic unit Naa40p (Nat4) which co-translationally Nt-acetylates histones H2A and H4. Recombinant hNaa40p Nt-acetylates the oligopeptides derived from the N-termini of both histones |