EC Number |
Natural Substrates |
---|
2.3.1.24 | acyl-CoA + sphingosine |
LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate PtdCho metabolism in pulmonary epithelia |
2.3.1.24 | D-sphingosine + palmitoyl-CoA |
- |
2.3.1.24 | dihydrosphingosine + myristoyl-CoA |
- |
2.3.1.24 | dihydrosphingosine + palmitoyl-CoA |
- |
2.3.1.24 | dihydrosphingosine + palmitoyl-CoA |
best substrate |
2.3.1.24 | dihydrosphingosine + stearoyl-CoA |
- |
2.3.1.24 | more |
the enzyme catalyzes the synthesis of significantly more 17C16- and 17C24:1-ceramides and significantly less 17C22:0-, 17C24:0, and 17C26:0-ceramides in vivo, analysis of sphingosine and ceramidases in different cells, overview |
2.3.1.24 | more |
CERS4 transfers C18 and C20 fatty acids |
2.3.1.24 | more |
CERS5 transfers C16 fatty acids, and potentially also C14 and C18 fatty acids |
2.3.1.24 | more |
CerS6 lysate produces nonhydroxy-dihydro-ceramides that included strong bands for C14:0- and C16:0-dihydro-ceramide, but a weak band for C18:0-dihydro-ceramide |