EC Number |
Natural Substrates |
---|
2.1.1.57 | more |
maximum 2'O-MTase activity requires the cap and at least 6 nucleotides |
2.1.1.57 | more |
the enzyme shows highest activity towards 7Me-GpppA-Cn where n equals at least four, and does not methylate GpppAC5 or pppAC5 |
2.1.1.57 | S-adenosyl-L-methionine + 7Me-GpppA-C5 |
- |
2.1.1.57 | S-adenosyl-L-methionine + 7Me-GpppA-C5 |
exclusive methylation at the 2'O position |
2.1.1.57 | S-adenosyl-L-methionine + 7Me-GpppA-Cn |
exclusive methylation at the 2'O position |
2.1.1.57 | S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] |
- |
2.1.1.57 | S-adenosyl-L-methionine + GpppA-Cn |
exclusive methylation at the 2'O position |
2.1.1.57 | S-adenosyl-L-methionine + m7G(5')pppR-RNA |
RNA-polymerase holoenzyme has methyltransferase activity: the same protein acts as methyltransferase and poly(A)-polymerase stimulatory factor VP39 |
2.1.1.57 | S-adenosyl-L-methionine + m7G(5')pppR-RNA |
final step in formation of 7-methylguanosine(5')pppNm-cap structure of viral RNA |