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Results 1 - 9 of 9

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.1.1.361	3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20	-
2.1.1.361	more	enzyme binding to the nucleosome protects it from degradation during the cell cycle. Full length enzyme has 3.8% of its histone methyltransferase activity on nucleosomes containing the H2A/E61A/ E64A/D90A/E92A mutations compared to wild type nucleosomes
2.1.1.361	more	the enzyme is completely inactive toward histone H4 with a K20L mutation
2.1.1.361	more	the proteolytic degradation of the enzyme is controlled by the SCFSlimb ligase complex
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-L-lysine20	-
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-L-lysine20	highly specific substrate
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-N6,N6-dimethyl-L-lysine20	-
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20	-
2.1.1.361	S-adenosyl-L-methionine + [p53]-L-lysine382	-

Results 1 - 9 of 9

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Release 2023.1 (January 2023)