EC Number |
Natural Substrates |
---|
2.1.1.360 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 |
overall reaction |
2.1.1.360 | more |
AF10 bound to the enzyme simultaneously senses unmodified histone H3 lysine 27 via its PHD finger-Zn knuckle-PHD finger domain and enables the enzyme to methylate histone H3 at lysine 79. Knockout embryos, lacking Af10, have reduced [histone H3]-N6-methyl-L-lysine79 in developing nasal processes and reduced expression of AP2alpha, a gene required for cranial neural crest cell development |
2.1.1.360 | S-adenosyl-L-methionine + a [histone H3]-L-lysine79 |
- |
2.1.1.360 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 |
- |
2.1.1.360 | S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 |
- |
2.1.1.360 | S-adenosyl-L-methionine + histone L-lysine |
- |
2.1.1.360 | S-adenosyl-L-methionine + [histone H3]-L-lysine79 |
- |
2.1.1.360 | S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine79 |
- |