EC Number   |
Natural Substrates |
|---|
   2.1.1.246 | a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M |
- |
| 2.1.1.246 | a [methyl-Co(III) methanol-specific corrinoid protein] + CoM |
- |
| 2.1.1.246 | more |
transferase MtaA catalyzes the transfer of the methyl group from methylated transferase MtaBC to coenzyme M. Instead of methylated transferase MtaBC, MtaA can also use free methylcobalamin as the methyl donor. MtaA activates coenzyme M for nucleophilic attack of the methyl group of the methylcobamide |
| 2.1.1.246 | more |
conversions of monomethylamine and dimethylamine to CH3-SCoM are dependent upon MT2-A, and are not supported by MT2-M. In contrast, MT2-M acts specifically in metabolism of methanol, but does not substitute for MT2-A in conversion of monomethylamine or dimethylamine. Nevertheless, both isozymes are capable of supporting the conversion of trimethylamine |
| 2.1.1.246 | more |
methyltransferase 2, MT2, transfers the methyl group from the methylated corrinoid protein to coenzyme M, i.e. 2-mercaptoethanesulfonic acid. Methyl-coenzyme M is then disproportionated, with one molecule being oxidized to CO2 to provide the six electrons required for reduction of three additional methyl-coenzyme M molecules to methane |
