EC Number |
Natural Substrates |
---|
1.5.1.33 | 2 biopterin + 3 NADPH + 3 H+ |
essential enzyme of pterin and folate metabolism |
1.5.1.33 | 2 biopterin + 3 NADPH + 3 H+ |
salvage of pterins, enzyme acts as a metabolic bypass for drugs targeting dihydrofolate reductase, PTR1 contributes about 10% of the reduction of folates in wild-type cells while the remaining 90% is due to the activity of dihydrofolate reductase-thymidylate synthase (EC 1.5.1.3) |
1.5.1.33 | 6-biopterin + NADPH + H+ |
- |
1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
- |
1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
best substrate |
1.5.1.33 | 7,8-dihydrofolate + NADPH + H+ |
- |
1.5.1.33 | biopterin + 2 NADPH + 2 H+ |
- |
1.5.1.33 | biopterin + NADPH + H+ |
- |
1.5.1.33 | dihydrobiopterin + NADPH + H+ |
- |
1.5.1.33 | folate + NADPH + H+ |
- |