EC Number   |
Natural Substrates |
|---|
   1.4.3.13 | collagen + H2O + O2 |
- |
| 1.4.3.13 | collagen + H2O + O2 |
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity |
| 1.4.3.13 | collagen III + O2 + H2O |
- |
| 1.4.3.13 | elastin + H2O + O2 |
- |
| 1.4.3.13 | elastin + H2O + O2 |
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity |
| 1.4.3.13 | more |
lysyl oxidase gene family. Enzyme seems to be involved in binding and crosslinking to other cell-surface and extracellular-matrix proteins |
| 1.4.3.13 | more |
enzyme is responsible for the cross-linking of collagen and elastin, and is required for vascular and diaphragmatic development during embryogenesis |
| 1.4.3.13 | more |
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments |
| 1.4.3.13 | more |
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments, enzyme expression in downregulated in Menkes disease, a disorder of copper transport |
| 1.4.3.13 | more |
expression of isozymes LOXL1,3,4 during osteoblast differentiation is highly regulated due to their distinct roles in collagen matrix stabilization and subsequent mineralization |
