EC Number   |
Natural Substrates |
|---|
    1.4.1.4 | 2-oxoglutarate + NADPH + NH3 |
ammonia-assimilating enzyme |
| 1.4.1.4 | 2-oxoglutarate + NADPH + NH3 |
the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus |
| 1.4.1.4 | 2-oxoglutarate + NH3 + NADPH + H+ |
- |
| 1.4.1.4 | L-glutamate + H2O + NADP+ |
- |
| 1.4.1.4 | L-glutamate + H2O + NADP+ |
reaction cycle, specificities of forward and reverse reactions, overview |
| 1.4.1.4 | L-glutamate + NADP+ + H2O |
- |
| 1.4.1.4 | more |
glutamate dehydrogenase represents an enzymatic link between major catabolic and biosynthetic pathways via the tricarboxylic acid cycle intermediate 2-oxoglutarate |
| 1.4.1.4 | more |
glutamate dehydrogenase functions physiologically for the synthesis of L-glutamate from 2-oxoglutarate and ammonia |
| 1.4.1.4 | more |
enzyme synthesis is increased under hyperosmotic conditions in the halotolerant yeast |
| 1.4.1.4 | more |
the enzyme is encoded by gdhA. In strains expressing high levels of gdhA mRNA, two promoters, gdhA P1 and gdhA P2, initiate transcription of gdhA. In strains expressing low mRNA levels, gdhA P2 is not active because of weak expression of GdhR, an associated regulatory gene. 2-Oxoglutarate inhibits binding of GdhR to gdhA P2 |
