EC Number   |
Natural Substrates |
|---|
    1.4.1.2 | 2-oxoglutarate + NH3 + NADH |
in conjugation with glutamine synthase, the glutamate dehydrogenase plays a major role in controlling the translocation of organic carbon and nitrogen metabolites in both vegetative and reproductive organs. It is possible that the presence of glutamate dehydrogenase in multivesicular bodies within the flower receptacle is important for the recycling of carbon and nitrogen molecules in senescing tissues in which the enzyme is generally induced |
| 1.4.1.2 | L-glutamate + H2O + NAD+ |
- |
| 1.4.1.2 | L-glutamate + H2O + NAD+ |
control point for amino acid metabolism |
| 1.4.1.2 | L-glutamate + H2O + NAD+ |
primary role in squid mantle muscle is in regulating the catabolism of amino acids for energy production |
| 1.4.1.2 | L-glutamate + H2O + NAD+ |
the enzyme may be linked to oxygen through an electron-transport system |
| 1.4.1.2 | L-glutamate + H2O + NAD+ |
reaction cycle, specificities of forward and reverse reactions, overview |
| 1.4.1.2 | L-glutamate + H2O + NAD+ |
AtGDH1 activity in the forward reaction (oxidative deamination) is physiologically more relevant due to the high NAD+/NADH ratio in plant mitochondria |
| 1.4.1.2 | more |
in yeast, NADP+-dependent enzymes, EC 1.4.1.4, encoded by GDH1 and GDH3, are reported to synthesize glutamate from 2-oxtoglutarate, while an NAD+-dependent enzyme, EC 1.4.1.2, encoded by GDH2, catalyzes the reverse reaction. Gdh1p is the primary GDH enzyme and Gdh2p and Gdh3p play evident roles during aerobic glutamate metabolism |
