EC Number   |
Natural Substrates |
|---|
    1.2.1.24 | 4-hydroxy-trans-2-nonenal + NAD+ |
elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria |
| 1.2.1.24 | 4-hydroxy-trans-2-nonenal + NAD+ + H2O |
- |
| 1.2.1.24 | more |
deficiency of succinate semialdehyde dehydrogenase is a rare autosomal recessively inherited metabolic disorder that results in acumulation of 4-hydroxybutyrate. Functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency |
| 1.2.1.24 | more |
ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging |
| 1.2.1.24 | succinate semialdehyde + NAD+ + H2O |
enzyme of agmatine degradation |
| 1.2.1.24 | succinate semialdehyde + NAD+ + H2O |
enzyme may play an important role, not only in metabolizing succinate semialdehyde but also in oxidation of aromatic aldehydes in the soil environment |
| 1.2.1.24 | succinate semialdehyde + NAD+ + H2O |
enzyme is induced by growth on gamma-aminobutyrate |
| 1.2.1.24 | succinate semialdehyde + NAD+ + H2O |
enzyme is involved in the catabolism of the neurotransmitter 4-aminobutyrate |
| 1.2.1.24 | succinate semialdehyde + NAD+ + H2O |
enzyme is induced by succinate semialdehyde, functions in the oxidation of succinate semialdehyde during growth on both 4-hydroxyphenylacetate and 4-aminobutyrate |
| 1.2.1.24 | succinate semialdehyde + NAD+ + H2O |
induced by pyridine, the enzyme is involved in the degradation of pyridine |
