EC Number |
Natural Substrates |
---|
1.17.4.1 | ADP + thioredoxin |
the enzyme converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair |
1.17.4.1 | CDP + thioredoxin |
- |
1.17.4.1 | CDP + thioredoxin |
the enzyme converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair |
1.17.4.1 | GDP + thioredoxin |
- |
1.17.4.1 | more |
DNA damage checkpoints modulate RNR activity through the temporal and spatial regulation of its subunits |
1.17.4.1 | more |
each catalytic turnover by aerobic ribonucleotide reductase requires the assembly of the two proteins, R1 (alpha2) and R2 (beta2), to produce deoxyribonucleotides for DNA synthesis |
1.17.4.1 | more |
the Sml1-R1 interaction causes SML1-dependent lethality, the CX2C motif of Rnr1 Is essential for viability. overview |
1.17.4.1 | more |
human p53R2 is a 351-residue p53-inducible ribonucleotide reductase small subunit, hp53R2 supplies dNTPs for DNA repair to cells in G0-G1 in a p53-dependent fashion, rather than exhibiting cyclic dNTP synthesis. Hp53R2 structure-function relationship determination and analysis, overview |
1.17.4.1 | more |
ribonucleotide reductases catalyze the reduction of ribonucleotides to deoxyribonucleotides for DNA synthesis |
1.17.4.1 | more |
ribonucleotide reduction is the unique step in DNA-precursor biosynthesis and involves radical-dependent redox chemistry and diverse metallo-cofactors, overview. The Mn-RNR from the Gram-positive bacterium Corynebacterium ammoniagenes, strain ATCC 6872, belongs a distinct RNR class IV enzyme |