EC Number |
Natural Substrates |
---|
1.14.99.14 | 11-deoxycorticosterone + AH2 + O2 |
- |
1.14.99.14 | 11-deoxycortisol + AH2 + O2 |
- |
1.14.99.14 | 16alpha,17-epoxyprogesterone + AH2 + O2 |
- |
1.14.99.14 | 17alpha-hydroxyprogesterone + AH2 + O2 |
- |
1.14.99.14 | more |
the enzyme is capable of converting useful pharmaceutical targets such as 3-oxo-DELTA4-steroids (e.g., testosterone, 11-deoxycorticosterone, androstenedione, and progesterone) mainly into their 15beta-hydroxy homologues. In addition, the enzyme hydroxylates progesterone to a minor extent at the 11alpha-, 9alpha-, and 6beta-positions |
1.14.99.14 | progesterone + AH2 + O2 |
- |
1.14.99.14 | progesterone + NADPH + O2 |
- |
1.14.99.14 | progesterone + NADPH + O2 |
activity dependent upon NADPH and O2 |
1.14.99.14 | progesterone + NADPH + O2 |
multicomponent monooxygenase system |
1.14.99.14 | progesterone + NADPH + O2 |
necessary step in the synthesis of cortico-steroid hormones |