EC Number   |
Natural Substrates |
|---|
    1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 |
a key step in bile acid synthesis |
| 1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 |
activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview |
| 1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 |
the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview |
| 1.14.14.139 | 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 |
key enzyme for the formation of cholic acid |
| 1.14.14.139 | 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 |
microsomal enzyme activity was markedly elevated by starvation or streptozotocin administration to the animals |
| 1.14.14.139 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.139 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
dietary cholsterol and cholic acid have an influence of enzyme regulation |
| 1.14.14.139 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview |
| 1.14.14.139 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
the enzyme is necessary for the synthesis of cholic acid |
