EC Number |
Natural Substrates |
---|
1.14.13.128 | 1,3,7-trimethylxanthine + O2 + NAD(P)H + H+ |
i.e. caffeine |
1.14.13.128 | 1,3,7-trimethylxanthine + O2 + NADPH + H+ |
i.e. caffeine |
1.14.13.128 | 7-methylxanthine + O2 + NAD(P)H + H+ |
- |
1.14.13.128 | 7-methylxanthine + O2 + NAD(P)H + H+ |
part of the caffeine degradation pathway in Pseudomonas putida |
1.14.13.128 | 7-methylxanthine + O2 + NADH + H+ |
- |
1.14.13.128 | 7-methylxanthine + O2 + NADH + H+ |
specific substrate |
1.14.13.128 | 7-methylxanthine + O2 + NADH + H+ |
the N7-demethylation reaction absolutely requires a unique, tightly bound protein complex composed of NdmC, NdmD, and NdmE. NdmE functions as a noncatalytic subunit that serves a structural role in the complexation of the oxygenase (NdmC) and Rieske domains (NdmD) |
1.14.13.128 | 7-methylxanthine + O2 + NADH + H+ |
immediate degradation via the NdmCDE complex |
1.14.13.128 | caffeine + O2 + NADH + H+ |
- |
1.14.13.128 | more |
the metabolite is 1,3-dimethylxanthine, i.e. theophylline, is produced by the demethylation in the 7th position of the purine ring, mainly in fungi, overview |