EC Number   |
Natural Substrates |
|---|
   1.14.11.67 | histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 |
- |
| 1.14.11.67 | histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 |
SE14 catalyzes H3K4me3 demethylation in the promoter region of RFT1 |
| 1.14.11.67 | histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 |
yeast Jhd2 demethylates histone H3 Lys4 near the rDNA locus, Jhd2 demethylates H3K4 within the rDNA regions in vivo |
| 1.14.11.67 | histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 |
- |
| 1.14.11.67 | histone H3 N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 |
- |
| 1.14.11.67 | histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 |
- |
| 1.14.11.67 | more |
histone H3K4 demethylases are essential in development and differentiation |
| 1.14.11.67 | more |
isoform dJMJD2(1)/CG15835 regulates heterochromatin organization. It is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates trimethylated histone 3 lysine 36 methylation |
| 1.14.11.67 | more |
Lid is required for Myc-induced cell growth |
| 1.14.11.67 | more |
RB-binding protein 2, RBP2, is a key effector for retinoblastoma protein mediating cell-cycle withdrawal and differentiation by interacting with a variety of proteins. During differentiation, RBP2 exerts inhibitory effects on multiple genes through direct interaction with their promoters. RBP2 shows high correlation with the presence of H3K4me3, and its target genes are separated into two functionally distinct classes: differentiation-independent and differentiation-dependent genes. Molecular mechanisms of RBP2 regulation of differentiation, overview. Functional analysis of RBP2 target genes and differentially expressed genes, overview |
