EC Number   |
Natural Substrates |
|---|
   1.11.1.24 | 2 thioredoxin + ROOH |
- |
| 1.11.1.24 | more |
1-Cys peroxiredoxin protects DNA from degradation by reactive O2 species in presence of low molecular mass thiols such as dithiothreitol and glutathione |
| 1.11.1.24 | more |
after subjection to exogenous and endogenous oxidative stress, the Plasmodium falciparum blood stage form shows a marked elevation of PfTrx-Px1 mRNA and protein levels consistent with the structure of related proteins |
| 1.11.1.24 | more |
peroxidases belonging to the class of 1-Cys and 2-Cys peroxiredoxins play crucial roles in maintaining redox balance. TgTrx-Px1 is an extremely potent antioxidant |
| 1.11.1.24 | more |
the enzyme is essential for sustaining life span of erythrocytes in mice by protecting them from oxidative stress |
| 1.11.1.24 | more |
the enzyme might function as a major antioxidant enzyme in Ascaris suum |
| 1.11.1.24 | more |
the enzyme plays a critical role in defending the organism against oxygen toxicity |
| 1.11.1.24 | more |
the enzyme promotes potassium efflux and down-regulates apoptosis and the recruitment of monocytes by endothelial tissue |
| 1.11.1.24 | more |
the midpoint redox potential of -315 mV places 2-Cys Prx reduction after Calvin cycle activation and before switching the male valve for export of excess reduction equivalents to the cytosol. The activity of the enzyme is also linked to chloroplastic NAD(P)H metabolism. Saline-stress-induced oligomerization of the enzyme triggers membrane attachment and allows for detoxification of peroxides at the site of production in immediate vicinity of the thylakoid membrane |
| 1.11.1.24 | more |
together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism. In addition Prx I and II might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentration of H2O2 |
