EC Number   |
Natural Substrates |
|---|
    1.1.1.64 | 17beta-estradiol + NADP+ |
- |
| 1.1.1.64 | 5beta-androstane-3alpha,17beta-diol + NADP+ |
- |
| 1.1.1.64 | androst-4-ene-3,17-dione + NADPH |
the enzyme plays a central role in the development of the male phenotype. Mutations that inactivate the enzyme give rise to a rare form of male pseudohermaphroditism, referred to as 17beta-HSD-3 deficiency |
| 1.1.1.64 | androst-4-ene-3,17-dione + NADPH |
convertion of the weak androgen androstendione into the potent androgen testosterone |
| 1.1.1.64 | androstenedione + NADPH + H+ |
- |
| 1.1.1.64 | androstenedione + NADPH + H+ |
the enzyme is involved in biosynthesis of testosterone |
| 1.1.1.64 | androstenedione + NADPH + H+ |
the two reactions 11beta-HSD1-dehydrogenase, EC 1.1.1.146, and 17beta-HSD3, EC 1.1.1.64, which utilize NADPH are competing for NADPH from the same cofactor pool. 11beta-HSD1-dehydrogenase serves as a NADPH-regenerating system that is tightly coupled in regulating 17beta-HSD3 reaction synthesizing testosterone. A cycle can exist whereby the NADPH produced by 11beta-HSD1 dehydrogenase can drive the reductase activity of 17beta-HSD3 and the NADP+ produced by 17beta-HSD3 and other enzymes involved in testosterone biosynthesis can drive the dehydrogenase activity of 11beta-HSD1 |
| 1.1.1.64 | testosterone + NAD+ |
NADP+ is preferred |
| 1.1.1.64 | testosterone + NADP+ |
- |
| 1.1.1.64 | testosterone + NADP+ |
17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred |
