EC Number   |
Natural Substrates |
|---|
    1.1.1.40 | (S)-malate + NAD(P)+ |
the unique and specialized C4-type enzyme has evolved fro the C3-type enzyme |
| 1.1.1.40 | (S)-malate + NAD+ |
when the R221G/K228R/I310V mutant is used with NADH, the mutant gives 1.2 and 2.7 times higher malate concentration than the wild-type with NADPH and NADH, respectively. These results can be partly explained by the alteration of the cofactor preference of the mutant enzyme, since the half-life of NADH is approximately 1.3times longer than that of NADPH at 50°C. However, the Km of the triple mutant for NAD+ remains 190times higher than that of the wild-type for NADP+ |
| 1.1.1.40 | (S)-malate + NADP+ |
- |
| 1.1.1.40 | (S)-malate + NADP+ |
enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 |
| 1.1.1.40 | (S)-malate + NADP+ |
major role of the enzyme is believed to be the supplier of NADPH for the reductive steps of lipogenesis |
| 1.1.1.40 | (S)-malate + NADP+ |
enzyme is involved in fatty acid biosynthesis in oil seed leucoplasts, overview |
| 1.1.1.40 | (S)-malate + NADP+ |
no day/night regulation of the isozyme 2 in leaves via expression level but by metabolite inhibition, overview |
| 1.1.1.40 | (S)-malate + NADP+ |
responsible for pyruvate and NADPH production |
| 1.1.1.40 | (S)-malate + NADP+ |
MEs are essential enzymes for growth on TCA cycle intermediates or on substrates that enter central metabolism via acetyl-coenzyme A, the reaction plays a role in the C4 metabolism, regulation, overview |
| 1.1.1.40 | (S)-malate + NADP+ |
NADP-ME provides a high CO2 concentration for Rubisco fixation in the C4 leaf chloroplasts, regulation of isozyme Hvme1, overview |
