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EC Number
Natural Substrates
Commentary (Nat. Sub.)
1.1.1.286
homoisocitrate + NAD+
-
1.1.1.286
homoisocitrate + NADP+
-
1.1.1.286
isocitrate + NAD+
-
1.1.1.286
isocitrate + NADP+
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1.1.1.286
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the enzyme catalyzes the fourth reaction of the alpha-aminoadipate pathway for lysine biosynthesis, the conversion of homoisocitrate to alpha-ketoadipate using NAD+ as an oxidizing agent
1.1.1.286
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in contrast to other homoisicitrate dehydrogenases, the homoisocitrate dehydrogenase from the thermophilic bacterium Thermus thermophilus (TtHICDH) catalyzes the reactions using both homoisocitrate and isocitrate as substrates at similar efficiencies
1.1.1.286
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Saci_2375 exhibits distinct and similar activities for isocitrate and homoisocitrate, but no detectable activity for 3-isopropylmalate. Saci_2375 is a dual function enzyme serving as isocitrate-homoisocitrate dehydrogenase
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