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Results 1 - 8 of 8
EC Number
Natural Substrates
Commentary (Nat. Sub.)
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enzyme expressed in K-562 cell is cytotoxic and cytostatic, IC50 value 0.0009 mM
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enzyme is both angiogenic and bactericidal. Domains II, amino acids 71-76, and III, amino acids 89-104, of RNase A-2 are both important for bactericidal activity
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isoform RNase1 is bactericidal with potent activities against the gramnegative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus
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isoform RNase2 is bactericidal with potent activities against the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus
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isoform RNase3 is bactericidal with potent activities against the gramnegative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus
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the enzyme degrades single-stranded and/or double-stranded RNA
RNA + H2O
-
RNA + H2O
endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA
Results 1 - 8 of 8