EC Number   |
Natural Substrates  |
|---|
   3.7.1.4 | baohuoside I + H2O |
- |
| 3.7.1.4 | dihydrochalcone phloretin + H2O |
- |
| 3.7.1.4 | epimedin A + H2O |
- |
| 3.7.1.4 | epimedin B + H2O |
- |
| 3.7.1.4 | epimedin C + H2O |
- |
| 3.7.1.4 | icariin + H2O |
the metabolic pathways of icariin by rat intestinal flora and enzyme solution are basically the same, including 3-O-rhamnose, 7-O-glucose hydrolysis or dual 3, 7-hydrolysis. Compared to 3-O-rhamnose and dual hydrolysis of 3, 7-, the 7-O-glucose hydrolysis is easier. The yielded metabolites contain M1 (icariside I), M2 (icaritin), and baohuoside I |
| 3.7.1.4 | monoacetylphloroglucinol + H2O |
- |
| 3.7.1.4 | more |
hydrolysis of prenylated flavonoids from Epimedium sp., Epimedii herba, used for a tranditional chinese medicine tonic, Yinyanghuo. Comparison of hydrolysis rates and substrate specificities of intestinal flora and intestinal enzymes, especially lactase phlorizin hydrolase, with the flavonoid substrates, overview. Flavonoid metabolic rates with rat intestinal enzyme are higher than those with intestinal flora. The intestinal hydrolysis of glycosides by intestinal enzymes is rapid. Even icariin is completely metabolized in 6 h and the epimedin A is totally metabolized in 12 h in incubation with intestinal enzyme |
| 3.7.1.4 | phloretin + H2O |
- |
| 3.7.1.4 | phloretin + H2O |
during flavonoid degradation |
