EC Number   |
Natural Substrates  |
|---|
   3.4.23.36 | bacterial lipoprotein + H2O |
- |
| 3.4.23.36 | bacterial lipoprotein + H2O |
cleavage of the signal peptide, the enzyme is essential for lipoprotein biosynthesis |
| 3.4.23.36 | FKBP8 + H2O |
i.e. SCSLVLEHQPDNIK |
| 3.4.23.36 | heme oxygenase 1 + H2O |
- |
| 3.4.23.36 | invariant chain CD74 of the major histocompatibility II complex + H2O |
- |
| 3.4.23.36 | more |
processing of the lipid-modified prolipoproteins |
| 3.4.23.36 | more |
signal peptidases are integral components of the secretory pathway |
| 3.4.23.36 | more |
lipoprotein processing by LspA is required for virulence of the organism and acts as virulence determinant of tuberculosis |
| 3.4.23.36 | more |
essential component of lipoprotein processing |
| 3.4.23.36 | more |
processing of prolipoproteins seems to be conserved among different bacterial species, and requires type II signal peptidase mediated cleavage of the N-terminal signal peptide to form the mature lipoprotein. Deletion of Sp0928 prevented processing of Streptococcus pneumoniae prolipoproteins to mature lipoproteins |
