EC Number |
Natural Substrates |
---|
3.4.22.B75 | SUMOylated c-Myc + H2O |
- |
3.4.22.B75 | more |
a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent |
3.4.22.B75 | SUMO1-HP1 + H2O |
deSUMOylation |
3.4.22.B75 | SUMOylated KRAB-associated protein 1 + H2O |
enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 |
3.4.22.B75 | SUMO2/3ylated HP1alpha + H2O |
HP1alpha localizes at the pericentric heterochromatin, importance of SUMOylation in directing HP1alphaยs subnuclear localization, SUMO deconjugation by enzyme SENP7 |
3.4.22.B75 | SUMOylated HP1alpha + H2O |
SUMO deconjugation by enzyme SENP7 |
3.4.22.B75 | poly-SUMO-2 + H2O |
the C-terminal catalytic domain of SENP7 efficiently depolymerized poly-SUMO-2 chains but has undetectable activity against poly-SUMO-1 chains |
3.4.22.B75 | more |
the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1 |