EC Number   |
Natural Substrates  |
|---|
   3.4.21.27 | factor IX + H2O |
activation of Factor IX in the intrinsic coagulation cascade |
| 3.4.21.27 | factor IX + H2O |
- |
| 3.4.21.27 | factor IX + H2O |
factor XIa has a role in the intrinsic pathway of coagulation, and plays a significant role in venous thrombosis |
| 3.4.21.27 | factor IX + H2O |
factor XIa is essential for the optimal activation of FIX |
| 3.4.21.27 | factor IX + H2O |
two forms of activated factor XI are generated during coagulation, and each half of a factor XIa dimer behaves as an independent enzyme with respect to factor IX |
| 3.4.21.27 | factor IX + H2O |
after binding to factor XIa, factor IX undergoes a single cleavage to form the intermediate factor IXalpha. FIXalpha then rebinds to the A3 domain to undergo a second cleavage, generating factor IXalphabeta |
| 3.4.21.27 | factor V + H2O |
fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348 |
| 3.4.21.27 | factor VIII + H2O |
fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721 |
| 3.4.21.27 | pro-HGF + H2O |
the enzyme may regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis |
| 3.4.21.27 | prochemerin + H2O |
- |
