EC Number |
Natural Substrates |
---|
3.4.21.27 | factor IX + H2O |
- |
3.4.21.27 | prochemerin + H2O |
- |
3.4.21.27 | proteinase-activated receptor 1E + H2O |
- |
3.4.21.27 | factor IX + H2O |
activation of Factor IX in the intrinsic coagulation cascade |
3.4.21.27 | factor IX + H2O |
after binding to factor XIa, factor IX undergoes a single cleavage to form the intermediate factor IXalpha. FIXalpha then rebinds to the A3 domain to undergo a second cleavage, generating factor IXalphabeta |
3.4.21.27 | factor IX + H2O |
factor XIa has a role in the intrinsic pathway of coagulation, and plays a significant role in venous thrombosis |
3.4.21.27 | factor IX + H2O |
factor XIa is essential for the optimal activation of FIX |
3.4.21.27 | factor V + H2O |
fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348 |
3.4.21.27 | factor VIII + H2O |
fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721 |
3.4.21.27 | prochemerin chem163S + H2O |
prochemerin is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin forms with different levels of activity |